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NF-κB in DCs: it takes effort to be immature

Nature Medicine volume 17, pages 15541556 (2011) | Download Citation

The nuclear factor-κB (NF-κB) family of regulators is well known for mediating dendritic cell (DC) maturation—that is, the acquisition of the functions required for full activation of T cells. Paradoxically, a key member of this family, NF-κB1, is now also implicated in maintaining DCs in an immature state (pages 1663–1667).

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References

  1. 1.

    & Annu. Rev. Immunol. 27, 693–733 (2009).

  2. 2.

    , & Nat. Immunol. 12, 695–708 (2011).

  3. 3.

    et al. Nat. Med. 17, 1663–1667 (2011).

  4. 4.

    et al. Cell 65, 305–317 (1991).

  5. 5.

    et al. Sci. Signal. 4, ra11 (2011).

  6. 6.

    et al. J. Hepatol. 53, 519–527 (2010).

  7. 7.

    et al. Mol. Cell. Biol. 18, 5678–5689 (1998).

  8. 8.

    et al. Am. J. Pathol. 166, 695–708 (2005).

  9. 9.

    et al. Mol. Cell. Biol. 20, 9113–9119 (2000).

  10. 10.

    et al. Arthritis Rheum. 42, 2577–2582 (1999).

  11. 11.

    et al. Clin. Biochem. 41, 881–886 (2008).

  12. 12.

    et al. Eur. Cytokine Netw. 21, 285–291 (2010).

  13. 13.

    , , , & Inflamm. Allergy Drug Targets 10, 208–217 (2011).

Download references

Author information

Affiliations

  1. Rémi J. Creusot is in the Division of Immunology & Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

    • Rémi J Creusot

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The author declares no competing financial interests.

Corresponding author

Correspondence to Rémi J Creusot.

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DOI

https://doi.org/10.1038/nm.2586

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