Tissue factor and obesity, a two-way street

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Increasing rates of obesity and obesity-associated type 2 diabetes are threatening to reverse recent gains in reducing the rates of cardiovascular and thrombotic disease. A new study in obese mice shows that tissue factor, the principal initiator of coagulation, is also promoting the development of insulin resistance and obesity (pages 1490–1497).

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Figure 1: Crosstalk between metabolism, inflammation and coagulation.

Marina Corral

References

  1. 1

    Granger, D.N., Rodrigues, S.F., Yildirim, A. & Senchenkova, E.Y. Microcirculation 17, 192–205 (2010).

  2. 2

    Gregor, M.F. & Hotamisligil, G.S. Annu. Rev. Immunol. 29, 415–445 (2011).

  3. 3

    Olefsky, J.M. & Glass, C.K. Annu. Rev. Physiol. 72, 219–246 (2010).

  4. 4

    Darvall, K.A., Sam, R.C., Silverman, S.H., Bradbury, A.W. & Adam, D.J. Eur. J. Vasc. Endovasc. Surg. 33, 223–233 (2007).

  5. 5

    Riewald, M. & Ruf, W. Crit. Care 7, 123–129 (2003).

  6. 6

    Tilley, R. & Mackman, N. Semin. Thromb. Hemost. 32, 5–10 (2006).

  7. 7

    Esmon, C.T. Thromb. Res. 114, 321–327 (2004).

  8. 8

    Kassel, K.M. et al. Am. J. Pathol. 10.1016/j.ajpath.2011.07.015 (9 September 2011).

  9. 9

    Badeanlou, L. et al. Nat. Med. 17, 1490–1497 (2011).

  10. 10

    Opal, S.M. Crit. Care Med. 28, S77–S80 (2000).

  11. 11

    Leclerc, V. & Reichhart, J.M. Immunol. Rev. 198, 59–71 (2004).

  12. 12

    Hotamisligil, G.S. Nature 444, 860–867 (2006).

  13. 13

    Song, M.J., Kim, K.H., Yoon, J.M. & Kim, J.B. Biochem. Biophys. Res. Commun. 346, 739–745 (2006).

  14. 14

    Shi, H. et al. J. Clin. Invest. 116, 3015–3025 (2006).

  15. 15

    Ahamed, J. et al. Proc. Natl. Acad. Sci. USA 103, 13932–13937 (2006).

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Correspondence to Daniel A Lawrence.

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