An intrinsic antiviral mechanism is characterized in which the cytidine deaminase APOBEC3G leads to upregulation of ligands recognized by the natural killer (NK) cell-activating receptor NKG2D in HIV-infected cells, thus stimulating destruction of the infected cells by NK cells.
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Swami, M. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. Nat Med 17, 1199 (2011). https://doi.org/10.1038/nm.2526
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DOI: https://doi.org/10.1038/nm.2526
