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Memory in disguise

Nature Medicine volume 17, pages 1182–1183 (2011)Cite this article

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Memory T cells can be maintained for a lifetime, but the underlying mechanism has been hard to pin down. A new study identifies a subset of memory T cells with stem cell properties in humans and shows that these cells mediate a superior antitumor response in a mouse model of adoptive T cell therapy (pages 1290–1297).

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Figure 1: During an immune response, naive T cells (TN) are primed by antigen-presenting cells (APCs) in secondary lymphoid organs.

References

  1. Merkenschlager, M., Terry, L., Edwards, R. & Beverley, P.C. Eur. J. Immunol. 18, 1653–1661 (1988).

    Article  CAS  Google Scholar 

  2. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Nature 401, 708–712 (1999).

    Article  CAS  Google Scholar 

  3. Fearon, D.T., Manders, P. & Wagner, S.D. Science 293, 248–250 (2001).

    Article  CAS  Google Scholar 

  4. Lanzavecchia, A. & Sallusto, F. Nat. Rev. Immunol. 2, 982–987 (2002).

    Article  CAS  Google Scholar 

  5. Gattinoni, L. et al. Nat. Med. 15, 808–813 (2009).

    Article  CAS  Google Scholar 

  6. Gattinoni, L. et al. Nat. Med. 17, 1290–1297 (2011).

    Article  CAS  Google Scholar 

  7. Geginat, J., Lanzavecchia, A. & Sallusto, F. Blood 101, 4260–4266 (2003).

    Article  CAS  Google Scholar 

  8. Antia, R., Ganusov, V.V. & Ahmed, R. Nat. Rev. Immunol. 5, 101–111 (2005).

    Article  CAS  Google Scholar 

  9. Pepper, M. & Jenkins, M.K. Nat. Immunol. 12, 467–471 (2011).

    Article  CAS  Google Scholar 

  10. Lanzavecchia, A. & Sallusto, F. Science 290, 92–97 (2000).

    Article  CAS  Google Scholar 

  11. Araki, K. et al. Nature 460, 108–112 (2009).

    Article  CAS  Google Scholar 

  12. Pearce, E.L. et al. Nature 460, 103–107 (2009).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Federica Sallusto and Antonio Lanzavecchia are at the Institute for Research in Biomedicine, Bellinzona, Switzerland.,

    Federica Sallusto & Antonio Lanzavecchia

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  1. Federica Sallusto
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  2. Antonio Lanzavecchia
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Correspondence to Federica Sallusto or Antonio Lanzavecchia.

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The authors declare no competing financial interests.

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Sallusto, F., Lanzavecchia, A. Memory in disguise. Nat Med 17, 1182–1183 (2011). https://doi.org/10.1038/nm.2502

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