Mutations in the microsatellite of the chaperone heat shock protein 110 (HSP110) yield a mutant protein that counteracts oncogenic potential, enhances responsiveness to chemotherapy and associates with increased survival in individuals with colorectal cancers that arise through defective DNA mismatch repair (pages 1283–1289).
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A.T.C. has served as a consult to Bayer HealthCare and Millennium Pharmaceuticals.
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Chan, A. Turning up the heat on colorectal cancer. Nat Med 17, 1186–1188 (2011). https://doi.org/10.1038/nm.2500
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DOI: https://doi.org/10.1038/nm.2500
