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Turning up the heat on colorectal cancer

Nature Medicine volume 17, pages 11861188 (2011) | Download Citation

Mutations in the microsatellite of the chaperone heat shock protein 110 (HSP110) yield a mutant protein that counteracts oncogenic potential, enhances responsiveness to chemotherapy and associates with increased survival in individuals with colorectal cancers that arise through defective DNA mismatch repair (pages 1283–1289).

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Author information

Affiliations

  1. Andrew T. Chan is in the Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

    • Andrew T Chan

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Competing interests

A.T.C. has served as a consult to Bayer HealthCare and Millennium Pharmaceuticals.

Corresponding author

Correspondence to Andrew T Chan.

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DOI

https://doi.org/10.1038/nm.2500

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