Targeting osteoclast-osteoblast communication

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  • A Corrigendum to this article was published on 06 December 2011

The identification of a new mode of cell-cell communication mediated by semaphorin 4D (Sema4D) and Plexin-B1 has added another level to the regulatory balance between bone formation and resorption (pages 1473–1480). This study also highlights Sema4D as a potential target for the development of new therapeutics for osteoporosis and other bone disorders associated with increased resorption.

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Figure 1: Mechanism of coupling between bone resorption and formation.

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Correspondence to Xu Cao.

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