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Epigenetic tumor suppression by BRCA1

BRCA1 germline mutations lead to an increased risk of breast and ovarian cancer, but the mechanisms by which the product of this gene functions as a tumor suppressor have remained elusive. Now, analysis of a missense BRCA1 variant shows that it can epigenetically regulate an miRNA implicated in cancer, providing new mechanistic insights (pages 1275–1282).

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Figure 1: BRCA1 can act as a tumor suppressor by epigenetically regulating the expression of the oncogenic miRNA-155.

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Correspondence to Alvaro N A Monteiro.

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The authors declare no competing financial interests.

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Velkova, A., Monteiro, A. Epigenetic tumor suppression by BRCA1. Nat Med 17, 1183–1185 (2011). https://doi.org/10.1038/nm.2493

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