BRCA1 germline mutations lead to an increased risk of breast and ovarian cancer, but the mechanisms by which the product of this gene functions as a tumor suppressor have remained elusive. Now, analysis of a missense BRCA1 variant shows that it can epigenetically regulate an miRNA implicated in cancer, providing new mechanistic insights (pages 1275–1282).
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The authors declare no competing financial interests.
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Velkova, A., Monteiro, A. Epigenetic tumor suppression by BRCA1. Nat Med 17, 1183–1185 (2011). https://doi.org/10.1038/nm.2493