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Epigenetic tumor suppression by BRCA1

Nature Medicine volume 17, pages 11831185 (2011) | Download Citation

BRCA1 germline mutations lead to an increased risk of breast and ovarian cancer, but the mechanisms by which the product of this gene functions as a tumor suppressor have remained elusive. Now, analysis of a missense BRCA1 variant shows that it can epigenetically regulate an miRNA implicated in cancer, providing new mechanistic insights (pages 1275–1282).

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Author information

Affiliations

  1. Aneliya Velkova and Alvaro N.A. Monteiro are at the Cancer Epidemiology Program at H. Lee Moffitt Cancer Center, Tampa, Florida, USA.

    • Aneliya Velkova
    •  & Alvaro N A Monteiro

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Alvaro N A Monteiro.

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DOI

https://doi.org/10.1038/nm.2493

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