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The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

Nature Medicine volume 17, pages 1217–1220 (2011)Cite this article

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Joseph Goldstein has written in this journal that creation (through invention) and revelation (through discovery) are two different routes to advancement in the biomedical sciences1. In my work as a phytochemist, particularly during the period from the late 1960s to the 1980s, I have been fortunate enough to travel both routes.

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Figure 1: A Handbook of Prescriptions for Emergencies by Ge Hong (284–346 CE).
Figure 2: Artemisia annua L.
Figure 3: Artemisinin.
Figure 4: Delegates at the fourth meeting of the Scientific Working Group on the Chemotherapy of Malaria in Beijing in 1981.

References

  1. Goldstein, J.L. Creation and revelation: two different routes to advancement in the biomedical sciences. Nat. Med. 13, 1151–1154 (2007).

    Article  CAS  Google Scholar 

  2. Collaboration Research Group for Qinghaosu. A new sesquiterpene lactone—qinghaosu [in Chinese]. Kexue Tongbao 3, 142 (1977).

  3. Liu, J.M. et al. Structure and reaction of qinghaosu [in Chinese]. Acta Chimi. Sin. 37, 129–143 (1979).

    CAS  Google Scholar 

  4. Collaboration research group for Qinghaosu. Studies on new anti-malarial drug qinghaosu [in Chinese]. Yaoxue Tongbao 14, 49–53 (1979).

  5. Collaboration research group for Qinghaosu. Antimalarial studies on qinghaosu [in Chinese]. Chin. Med. J. 92, 811–816 (1979).

  6. Tu, Y.Y. The awarded Chinese invention: antimalarial drug qinghaosu [in Chinese]. Rev. World Invent. 4, 26 (1981).

    Google Scholar 

  7. Tu, Y.Y. et al. Studies on the constituents of Artemisia annua L [in Chinese]. Yao Xue Xue Bao 16, 366–370 (1981).

    CAS  PubMed  Google Scholar 

  8. Tu, Y.Y., Ni, M.Y., Zhong, Y.R. & Li, L.N. Studies on the constituents of Artemisia annua L. and derivatives of artemisinin [in Chinese]. Zhongguo Zhong Yao Za Zhi 6, 31 (1981).

    CAS  Google Scholar 

  9. Tu, Y.Y. et al. Studies on the constituents of Artemisia annua L. (II). Planta Med. 44, 143–145 (1982).

    Article  CAS  Google Scholar 

  10. Collaboration Research Group for Qinghaosu. Chemical studies on qinghaosu. J. Tradit. Chin. Med. 2, 3–8 (1982).

  11. Xiao, Y.Q. & Tu, Y.Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore [in Chinese]. Yao Xue Xue Bao 19, 909–913 (1984).

    CAS  PubMed  Google Scholar 

  12. Tu, Y.Y., Yin, J.P., Ji, L., Huang, M.M. & Liang, X.T. Studies on the constituents of Artemisia annua L. (III) [in Chinese]. Chin. Tradit. Herbal Drugs 16, 200–201 (1985).

    Google Scholar 

  13. Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia apiacea Hance [in Chinese]. Chin. Tradit. Herbal Drugs 6, 2–3 (1985).

    Google Scholar 

  14. Tu, Y.Y., Zhu, Q.C. & Shen, X. Studies on the constituents of Young Artemisia annua L [in Chinese]. Zhongguo Zhong Yao Za Zhi 10, 419–420 (1985).

    CAS  Google Scholar 

  15. Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia gmelinii Web.exstechm [in Chinese]. Chin. Bull. Bot. 3, 34–37 (1985).

    Google Scholar 

  16. Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia argyi Levl et vant [in Chinese]. Zhongguo Zhong Yao Za Zhi. 10, 31–32 (1985).

    CAS  Google Scholar 

  17. Xiao, Y.Q. & Tu, Y.Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore [in Chinese]. Acta Bot. Sin. 28, 307–310 (1986).

    CAS  Google Scholar 

  18. Tu, Y.Y. Study on authentic species of Chinese herbal drug winghao [in Chinese]. Bull. Chin. Mater. Med. 12, 2–5 (1987).

    Google Scholar 

  19. Yin, J.P. & Tu, Y.Y. Studies on the constituents of Artemisia eriopoda Bunge [in Chinese]. Chin. Tradit. Herbal Drugs 20, 149–150 (1989).

    CAS  Google Scholar 

  20. Gu, Y.C. & Tu, Y.Y. Studies on chemical constituents of Artemisia japonica Thunb [in Chinese]. Chin. Tradit. Herbal Drugs 24, 122–124 (1993).

    CAS  Google Scholar 

  21. Klayman, D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049–1055 (1985).

    Article  CAS  Google Scholar 

  22. Sun, X.Z. et al. Experimental study on the immunosuppressive effects of qinghaosu and its derivatives [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 11, 37–38 (1993).

    Google Scholar 

  23. Yang, S.X., Xie, S.S., Ma, D., Long, Z.Z. & Tu, Y.Y. Immunologic enhancement and reconstitution by qinghaosu and its derivatives [in Chinese]. Chin. Bull. Pharm 9, 61–63 (1992).

    Google Scholar 

  24. Chen, P.H., Tu, Y.Y., Wang, F.Y., Li, F.W. & Yang, L. Effect of dihydroqinghaosu on the development of Plasmodium yoelii in Anopheles stephensi [in Chinese]. Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 16, 421–424 (1998).

    CAS  Google Scholar 

  25. Huang, L. et al. Studies on the antipyretic and anti-inflammatory effects of Artemisia annua L [in Chinese]. Zhongguo Zhong Yao Za Zhi 18, 44–48 (1993).

    CAS  PubMed  Google Scholar 

  26. Tu, Y.Y. The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu. Chin. Med. J. 112, 976–977 (1999).

    CAS  PubMed  Google Scholar 

  27. Xu, L.M., Chen, X.R. & Tu, Y.Y. Effect of hydroartemisinin on lupus BXSB mice [in Chinese]. Chin. J. Dermatovenerol. Integr. Tradit. West. Med. 1, 19–20 (2002).

    Google Scholar 

  28. Dong, Y.J. et al. Effect of dihydro-qinghaosu on auto-antibody production, TNFa secretion and pathologic change of lupus nephritis in BXSB mice [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 23, 676–679 (2003).

    PubMed  Google Scholar 

  29. Dong, Y.J. et al. The effects of DQHS on the pathologic changes in BXSB mice lupus nephritis and the effect mechanism [in Chinese]. Chin. Pharmacol. Bull. 19, 1125–1128 (2003).

    CAS  Google Scholar 

  30. Tu, Y.Y. The development of the antimalarial drugs with new type of chemical structure—qinghaosu and dihydroqinghaosu. Southeast Asian J. Trop. Med. Public Health 35, 250–251 (2004).

    CAS  PubMed  Google Scholar 

  31. Yang, L., Huang, M.M., Zhang, D. & Tu, Y.Y. Determination of scopoletin in qinghao by HPLC [in Chinese]. Chin. J. Exp. Tradit. Med. Formulae 12, 10–11 (2006).

    CAS  Google Scholar 

  32. Li, W.D., Dong, Y.J., Tu, Y.Y. & Lin, Z.B. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation. Int. Immunopharmacol. 6, 1243–1250 (2006).

    Article  CAS  Google Scholar 

  33. Zhang, D., Yang, L., Yang, L.X., Huang, M.M. & Tu, Y.Y. Determination of artemisinin, arteannuin B and artemisinic acid in Artemisia annua by HPLC-UV-ELSD [in Chinese]. Yao Xue Xue Bao 42, 978–981 (2007).

    CAS  PubMed  Google Scholar 

  34. Qinghao Ji Qinghaosulei Yaowu (Artemisia annua L., Artemisinin and its Derivatives) [in Chinese] (ed. Tu, Y.Y.) (Publisher of Chemical Industry, Beijing, 2009).

  35. Chen, G.Q. et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood 89, 3345–3353 (1997).

    CAS  PubMed  Google Scholar 

  36. Zhang, X.W. et al. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 328, 240–243 (2010).

    Article  CAS  Google Scholar 

  37. Tang, X.C. & Han, Y.F. Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb. CNS Drug Rev. 5, 281–300 (1999).

    Article  CAS  Google Scholar 

  38. Chen, K.J. et al. XS0601 reduces the incidence of restenosis: a prospective study of 335 patients undergoing percutaneous coronary intervention in China. Chin. Med. J. 119, 6–13 (2006).

    Article  CAS  Google Scholar 

  39. Gao, D. et al. The effect of Xuefu Zhuyu decoction on in vitro endothelial progenitor cell tube formation. Chin. J. Integr. Med. 16, 50–53 (2010).

    Article  CAS  Google Scholar 

  40. Zhao, N. et al. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am. J. Physiol. Heart Circ. Physiol. 298, H1166–H11176 (2010).

    Article  CAS  Google Scholar 

  41. Xu, X.S. et al. The antioxidant Cerebralcare Granule attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. Shock 32, 201–209 (2009).

    Article  CAS  Google Scholar 

  42. Sun, K. et al. Cerebralcare Granule, a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia–reperfusion. J. Ethnopharmacol. 130, 398–406 (2010).

    Article  Google Scholar 

  43. Han, J.Y. et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol. Ther. 117, 280–295 (2008).

    Article  CAS  Google Scholar 

  44. Liao, F. et al. Biomechanopharmacology: a new borderline discipline. Trends Pharmacol. Sci. 27, 287–289 (2006).

    Article  CAS  Google Scholar 

  45. You, Y. et al. Joint preventive effects of swimming and Shenlian extract on rat atherosclerosis. Clin. Hemorheol. Microcirc. 47, 187–198 (2011).

    PubMed  Google Scholar 

  46. Xie, L.X. et al. The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells. Clin. Hemorheol. Microcirc. 44, 245–258 (2010).

    CAS  PubMed  Google Scholar 

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Acknowledgements

I wish to express my heartfelt thanks to all my colleagues at the Academy of Traditional Chinese Medicine for their devotion to our work and for their exceptional contributions to the discovery and application of artemisinin and its derivatives. I thank my colleagues in the Shangdong Provincial Institute of Chinese Medicine, the Yunnan Provincial Institute of Materia Medica, the Institute of Biophysics and the Shanghai Institute of Organic Chemistry at the Chinese Academy of Sciences, Guangzhou University of Chinese Medicine and the Academy of Military Medical Sciences for their significant contributions to Project 523. I also would pay my respects to the leadership at the national Project 523 office and their sound efforts in organizing the malaria project activities.

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  1. Youyou Tu is at the Qinghaosu Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.,

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Tu, Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med 17, 1217–1220 (2011). https://doi.org/10.1038/nm.2471

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