Commentary | Published:

The NIH Clinical Center and the future of clinical research

Nature Medicine volume 17, pages 12211223 (2011) | Download Citation

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Building Ten at Fifty: 50 Years of Clinical Research at the NIH Clinical Center 26, 78 (U.S. Department of Health and Human Services, 2003).

  2. 2.

    New Clinical Center is a step toward better public health. New York Times (28 June 1953).

  3. 3.

    Minutes Medical Board of the Clinical Center Meeting (US National Institutes of Health, 13 March 1952).

  4. 4.

    in The Oxford University Textbook on Clinical Research Ethics (eds. Emanuel, E.J. et al.) Ch. 50, 543–544 (Oxford University Press, 2008).

  5. 5.

    , & Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc. Soc. Exp. Biol. Med. 93, 361–366 (1956).

  6. 6.

    et al. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood 13, 1126–1148 (1958).

  7. 7.

    , & Combination chemotherapy in the treatment of advanced Hodgkin's Disease. Ann. Intern. Med. 73, 881–895 (1970).

  8. 8.

    , & Lithium-carbonate treatment in depression and mania. A longitudinal double-blind study. Arch. Gen. Psychiatry 21, 486–496 (1969).

  9. 9.

    et al. Clomipramine treatment of childhood obsessive compulsive disorder. A double-blind controlled study. Arch. Gen. Psychiatry 42, 977–983 (1985).

  10. 10.

    , & Physiolgic dysfunction of dorsolateral prefrontal cortex in schizophrenia. 1. Regional cerebral blood flow evidence. Arch. Gen. Psychiatry 43, 114–124 (1986).

  11. 11.

    et al. Tangier Disease. Ann. Intern. Med. 55, 1016–1031 (1961).

  12. 12.

    Fat transport in lipoproteins-an integrated approach to mechanisms and disorders. N. Engl. J. Med. 276, 34–44 (1967).

  13. 13.

    et al. Administration of 3′-axido-3′-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet 327, 575–580 (1986).

  14. 14.

    et al. Screening test for HTLV-III (AIDS agent) antibodies. Specificity, sensitivity, and applications. J. Am. Med. Assoc. 253, 221–225 (1985).

  15. 15.

    Multifactoral nature of immunodeficiency virus disease: implications for therapy. Science 262, 1011–1018 (1993).

  16. 16.

    et al. NT5E mutations and arterial calcifications. N. Engl. J. Med. 364, 432–442 (2011).

  17. 17.

    & Focus on kidney cancer. Cancer Cell 6, 223–228 (2004).

  18. 18.

    et al. Documenting the location of prostate biopsies with image fusion. BJU Int. 107, 53–57 (2011).

  19. 19.

    et al. Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. 346, 570–578 (2002).

  20. 20.

    et al. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N. Engl. J. Med. 355, 581–592 (2006).

  21. 21.

    National Institutes of Health Scientific Management Review Board. Report on the NIH Clinical Center. (2010)

  22. 22.

    Taming clinical research's paper tigers. Clin. Cancer Res. Editorial 12, 4131 (2006).

  23. 23.

    et al. Central challenges facing the national clinical research enterprise. J. Am. Med. Assoc. 289, 1278–1287 (2003).

  24. 24.

    Reengineering translational science: the time is right. Sci. Transl. Med. 3, 1–6 (2011).

Download references

Acknowledgements

I thank M. Gormley and E. Gallin for helpful discussions and F. Ognibene, M. Gottesman and F. Collins for critical review of the manuscript.

Author information

Affiliations

  1. John I. Gallin is Director of the Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

    • John I Gallin

Authors

  1. Search for John I Gallin in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to John I Gallin.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm.2466

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing