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Cancer stem cells renew their impact

Nature Medicine volume 17, pages 1046–1048 (2011)Cite this article

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The cancer stem cell (CSC) concept has provocative implications for our understanding of cancer biology and therapy. Its clinical relevance now receives a major boost from the finding that a stem cell–like or self-renewing gene expression signature can predict clinical outcome in acute myeloid leukemia (pages 1086–1093).

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Figure 1: Possible mechanistic basis for the association between high self-renewal expression signature (SR) in AML (and other cancers) and poor clinical outcome.

Katie Vicari

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  1. Mel Greaves is in the Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, UK.,

    Mel Greaves

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  1. Mel Greaves
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Correspondence to Mel Greaves.

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The author declares no competing financial interests.

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Greaves, M. Cancer stem cells renew their impact. Nat Med 17, 1046–1048 (2011). https://doi.org/10.1038/nm.2458

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