The ribosomal protein RPL11 can block cell growth by boosting function of the tumor suppressor p53 in response to ribosomal stress, but the connection of this role with cancer has been obscure. New findings show that the nucleolar protein PICT1 can sequester RPL11, impairing p53 activation and favoring tumor growth (pages 944–951).
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Marina Corral
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Lu, H. A ribosomal tactic to halt cancer. Nat Med 17, 930–931 (2011). https://doi.org/10.1038/nm.2434
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DOI: https://doi.org/10.1038/nm.2434
