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GOAT links dietary lipids with the endocrine control of energy balance

An Erratum to this article was published on 01 September 2009

This article has been updated

Abstract

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

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Figure 1: Long-term fasting decreases Mboat4 expression and does not increase ghrelin acylation.
Figure 2: GOAT regulates energy homeostasis.

Change history

  • 04 September 2009

    In the version of this article initially published, the fourth condition from the top in the key to the bar graphs in Figure 2c was mislabeled as ‘mC8’. The correct label is ‘hC8’. The error has been corrected in the HTML and PDF versions of the article.

References

  1. 1

    Obici, S. et al. J. Clin. Invest. 108, 1079–1085 (2001).

    CAS  Article  Google Scholar 

  2. 2

    Schwartz, M.W., Woods, S.C., Porte, D. Jr., Seeley, R.J. & Baskin, D.G. Nature 404, 661–671 (2000).

    CAS  Article  Google Scholar 

  3. 3

    Cao, H. et al. Cell 134, 933–944 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Gillum, M.P. et al. Cell 135, 813–824 (2008).

    CAS  Article  Google Scholar 

  5. 5

    Kojima, M. et al. Nature 402, 656–660 (1999).

    CAS  Article  Google Scholar 

  6. 6

    López, M. et al. Cell Metab. 7, 389–399 (2008).

    Article  Google Scholar 

  7. 7

    Tschöp, M., Smiley, D.L. & Heiman, M.L. Nature 407, 908–913 (2000).

    Article  Google Scholar 

  8. 8

    Kamegai, J. et al. Diabetes 50, 2438–2443 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Tschöp, M. et al. J. Endocrinol. Invest. 24, RC19–RC21 (2001).

    Article  Google Scholar 

  10. 10

    Gutierrez, J.A. et al. Proc. Natl. Acad. Sci. USA 105, 6320–6325 (2008).

    CAS  Article  Google Scholar 

  11. 11

    Yang, J., Brown, M.S., Liang, G., Grishin, N.V. & Goldstein, J.L. Cell 132, 387–396 (2008).

    CAS  Article  Google Scholar 

  12. 12

    Nishi, Y. et al. Endocrinology 146, 2255–2264 (2005).

    CAS  Article  Google Scholar 

  13. 13

    Drazen, D.L., Vahl, T.P., D'Alessio, D.A., Seeley, R.J. & Woods, S.C. Endocrinology 147, 23–30 (2006).

    CAS  Article  Google Scholar 

  14. 14

    Liu, J. et al. J. Clin. Endocrinol. Metab. 93, 1980–1987 (2008).

    CAS  Article  Google Scholar 

  15. 15

    Dole, V.P. & Rizack, M.A. J. Lipid Res. 2, 90–91 (1961).

    CAS  Google Scholar 

  16. 16

    Schwartz, G.J. et al. Cell Metab. 8, 281–288 (2008).

    CAS  Article  Google Scholar 

  17. 17

    Zurier, R.B., Campbell, R.G., Hashim, S.A. & Van Itallie, T.B. N. Engl. J. Med. 274, 490–493 (1966).

    CAS  Article  Google Scholar 

  18. 18

    Prior, I.A., Davidson, F., Salmond, C.E. & Czochanska, Z. Am. J. Clin. Nutr. 34, 1552–1561 (1981).

    CAS  Article  Google Scholar 

  19. 19

    Pfluger, P.T. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G610–G618 (2008).

    CAS  Article  Google Scholar 

  20. 20

    Gauna, C. et al. Am. J. Physiol. Endocrinol. Metab. 293, E697–E704 (2007).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We would like to thank J.E. Baker, B. Berger and J. Holland for their outstanding technical support. This manuscript was supported by the Leibniz Graduate College (H.K.) and by the US National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant R01-DK069987 (to M.H.T.).

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Contributions

H.K., P.T.P. and J.A.G. designed and performed most of the experiments and wrote the manuscript; P.J.S. generated mouse models; J.A.W. performed and interpreted mass spectrometry analyses; T.A.C. performed gene expression analyses; A.S., H.-G.J., R.J.J. and J.E.H. designed experiments, interpreted data and wrote the manuscript; and M.L.H. and M.H.T. conceptualized, analyzed and interpreted all studies and wrote the manuscript.

Corresponding author

Correspondence to Matthias H Tschöp.

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Competing interests

J.A.G., P.J.S., T.A.C., J.A.W., J.E.H. and M.L.H. are employees and stock holders of the Eli Lilly Company.

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Supplementary Methods and Supplementary Figs. 1–7 (PDF 424 kb)

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Kirchner, H., Gutierrez, J., Solenberg, P. et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 15, 741–745 (2009). https://doi.org/10.1038/nm.1997

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