Artavanis, T. S., Matsuno, K. & Fortini, M. E. Notch signaling. Science 268, 225–232 (1995).
Schroeter, E. H., Kisslinger, J. A. & Kopan, R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393, 382–386 (1998).
Struhl, G. & Adachi, A. Nuclear access and action of notch in vivo. Cell 93, 649–660 (1998).
Tamura, K. et al. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H). Curr. Biol. 5, 1416–1423 (1995).
Kato, H. et al. Functional conservation of mouse Notch receptor family members. FEBS Lett. 395, 221–224 (1996).
Kurooka, H., Kuroda, K. & Honjo, T. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res. 26, 5448–5455 (1998).
de la Pompa, J. et al. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124, 1139–1148 (1997).
Kuroda, K. et al. Δ-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J. Biol. Chem. 274, 72138–7244 (1999).
Ohtsuka, T. et al. Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation. EMBO J. 18, 2196–2207 (1999).
Karanu, F. N. et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J. Exp. Med. 192, 1365–1372 (2000).
Li, L. et al. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity 8, 43–55 (1998).
Schroeder, T. & Just, U. Notch signalling via RBP-J promotes myeloid differentiation. EMBO J. 19, 2558–2568 (2000).
Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547–558 (1999).
Pui, J. C. et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11, 299–308 (1999).
Hua, H. et al. Inducible gene knockout of transcription factor RBP-J reveals its essential role in T versus B lineage decision. Int. Immunol. (in the press, 2002).
Morimura, T. et al. Cell cycle arrest and apoptosis induced by Notch1 in B cells. J. Biol. Chem. 275, 36523–36531 (2000).
Strobl, L. J. et al. Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2. J. Virol. 74, 1727–1735 (2000).
Morimura, T., Miyatani, S., Kitamura, D. & Goitsuka, R. Notch signaling suppresses IgH gene expression in chicken B cells: implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius. J. Immunol. 166, 3277–3283 (2001).
Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751–758 (1996).
Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190, 75–89 (1999).
Makowska, A., Faizunnessa, N. N., Anderson, P., Midtvedt, T. & Cardell, S. CD1 high B cells: a population of mixed origin. Eur. J. Immunol. 29, 3285–3294 (1999).
Martin, F. & Kearney, J. F. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12, 39–49 (2000).
Guinamard, R., Okigaki, M., Schlessinger, J. & Ravetch, J. V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nature Immunol. 1, 31–36 (2001).
Cariappa, A. et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity 5, 603–615 (2001).
Fukui, Y. et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412, 826–831 (2001).
Girkontaite, I. et al. Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nature Immunol. 9, 855–862 (2001).
Oka, C. et al. Disruption of the mouse RBP-J κ gene results in early embryonic death. Development 121, 3291–3301 (1995).
Rickert, R. C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25, 1317–1318 (1997).
Betz, U. A., Vosshenrich, C. A., Rajewsky, K. & Muller, W. Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr. Biol. 6, 1307–1316 (1996).
Roark, J. H. et al. CD1. 1 expression by mouse antigen-presenting cells and marginal zone B cells. J. Immunol. 160, 3121–3127 (1998).
Won, W. J., Masuda. K., Kearney, J. F. CD9 is a novel marker that dicriminates between marginal zone and follicular B cells. FASEB J. 14, 1191 (2000).
Radkov, S. A. et al. Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21. J. Virol. 71, 8552–8562 (1997).
Morelli, A. E. et al. Recombinant adenovirus induces maturation of dendritic cells via an NF-κB-dependent pathway. J. Virol. 74, 9617–9628 (2000).
Macpherson, A. J. et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222–2226 (2001).
Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427–1429 (1995).
Oliver, A. M., Martin, F., Gartland, G. L., Carter, R. H. & Kearney, J. F. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27, 2366–2374 (1997).
Bang, A. G., Bailey, A. M. & Posakony, J. W. Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev. Biol. 172, 479–494 (1995).
Cariappa, A., Liou, H. C., Horwitz, B. H. & Pillai, S. Nuclear factor κB is required for the development of marginal zone B lymphocytes. J. Exp. Med. 192, 1175–1182 (2000).
Rickert, R. C., Rajewsky, K. & Roes, J. B Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376, 352–355 (1995).
Sato, S., Steeber, D. A., Jansen, P. J. & Tedder, T. F. CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. J. Immunol. 158, 4662–4669 (1997).
Weih, D., Yilmaz, Z. & Weih, F. Essential role of rel-B in germinal center and marginal zone formation and proper expression of homing chemokines. J. Immunol. 167, 1909–1919 (2001).
Wang, J. H. et al. Aiolos regulates B cell activation and maturation to effector state. Immunity 9, 543–553 (1998).
Dunn, W. D. K., Isaacson, P. G. & Spencer, J. Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells. J. Exp. Med. 182, 559–566 (1995).
Martin, F. & Kearney, J. F. B1 cells: similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13, 195–201 (2001).
Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553–563 (2000).
Nakane, A., Okamoto, M., Asano, M., Kohanawa, M. & Minagawa, T. Endogenous γ interferon, tumor necrosis factor, and interleukin-6 in Staphylococcus aureus infection in mice. Infect. Immun. 63, 1165–1172 (1995).
deVos, T. & Dick, T. A. A rapid method to determine the isotype and specificity of coproantibodies in mice infected with Trichinella or fed cholera toxin. J. Immunol. Meth. 141, 285–8 (1991).
Kanegae, Y. et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res. 23, 3816–3821 (1995).
Tun, T. et al. Recognition sequence of a highly conserved DNA binding protein RBP-J κ. Nucleic Acids Res. 22, 965–971 (1994).
Zimber, S. U. et al. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jκ, the homologue of Drosophila Suppressor of Hairless. EMBO J. 13, 4973–4982 (1994).
Sakai, T. et al. Loss of immunostaining of the RBP-J κ transcription factor upon F9 cell differentiation induced by retinoic acid. J. Biochem. (Tokyo) 118, 621–628 (1995).