Abstract
Using gene expression profiling, we show here that activation of B cells and professional antigen-presenting cells (APCs) induces the expression of common chemokines. Among these, CCL4 was the most potent chemoattractant of a CD4+CD25+ T cell population, which is a characteristic phenotype of regulatory T cells. Depletion of either regulatory T cells or CCL4 resulted in a deregulated humoral response, which culminated in the production of autoantibodies. This suggested that the recruitment of regulatory T cells to B cells and APCs by CCL4 plays a central role in the normal initiation of T cell and humoral responses, and failure to do this leads to autoimmune activation.
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Acknowledgements
We thank D. Fearon for his support and critical reading of the manuscript; K. J. Patel, M. S. Neuberger and C. Rada for helpful discussions; T. Langford and her team for animal handling; and A. Johnson for assistance with cell sorting.
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Bystry, R., Aluvihare, V., Welch, K. et al. B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2, 1126–1132 (2001). https://doi.org/10.1038/ni735
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DOI: https://doi.org/10.1038/ni735
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