A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-γ (IFN-γ) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
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We thank S. S. Tevethia for assistance with the MHC tetramer protocols; D. M. Pardoll, J. P. Schneck and K. A. Kraemer for providing reagents, protocols and help in making IgG1 MHC dimers; and Y. Liu for technical assistance. Supported by National Institutes of Health research grants AR-35506 (to R. M. W.), AI-46578 (to L. K. S.) and Center Grant DK32520 (to I. J.). The contents of this publication are solely the responsibility of the authors and do not represent the official view of the National Institute of Health.
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Chen, H., Fraire, A., Joris, I. et al. Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol 2, 1067–1076 (2001). https://doi.org/10.1038/ni727
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