Nucleotide-binding oligomerization domain 2 (Nod2) is required for sensing of intracellular bacteria and subsequent inflammatory responses. Unexpectedly, new evidence suggests that Nod2 influences T helper cell signaling, proliferation and differentiation and effector responses against Toxoplasma gondii.
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Salek-Ardakani, S., Croft, M. T cells need Nod too?. Nat Immunol 10, 1231–1233 (2009). https://doi.org/10.1038/ni1209-1231
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DOI: https://doi.org/10.1038/ni1209-1231
