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Competition for cytokines: Treg cells take all

Thymus-derived regulatory T cells are thought to suppress target cells by either a cell contact–dependent mechanism or the production of inhibitory cytokines. A new study suggests a third strategy of apoptosis induced by the consumption of interleukin 2 and other T cell growth factors by regulatory T cells.

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Figure 1: Mechanisms of Treg cell supression.

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Scheffold, A., Murphy, K. & Höfer, T. Competition for cytokines: Treg cells take all. Nat Immunol 8, 1285–1287 (2007). https://doi.org/10.1038/ni1207-1285

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