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From antigen processing to peptide-MHC binding

Emil R. Unanue recounts his seminal work 25 years ago demonstrating that antigens are phagocytosed and processed by antigen-presenting cells and that class II major histocompatibility complex molecules are peptide-binding proteins.

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My appreciation goes to the many colleagues who spent time in my laboratory and participated in many facets of these studies. Among them I must single out Paul Allen. A special gratitude goes to Ita Askonas who introduced me to the field, and to Frank Dixon, the late John Humphrey and Baruj Benacerraf for their guidance during my formative years in their departments.

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Unanue, E. From antigen processing to peptide-MHC binding. Nat Immunol 7, 1277–1279 (2006).

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