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Pin1: a proline isomerase that makes you wheeze?

Nature Immunology volume 6, pages 1211–1212 (2005)Cite this article

The accumulation of eosinophils in lung tissue, an invariant feature of allergic asthma, requires autocrine production of the cytokine GM-CSF. New data suggest protein isomerization mediated by the enzyme Pin1 is key to the stability of GM-CSF mRNA and eosinophil survival.

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Figure 1: Pin1 stabilizes GM-CSF transcripts in response to eosinophil activation.

Katie Ris

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  1. Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA

    Paul Anderson

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Anderson, P. Pin1: a proline isomerase that makes you wheeze?. Nat Immunol 6, 1211–1212 (2005). https://doi.org/10.1038/ni1205-1211

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