The Toll-like receptor (TLR) family targets pathogen-derived molecules in regions unlikely to change under selection pressures. For TLR5, which recognizes the protein flagellin, the function of the targeting motif is key.
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Reichhart, JM. TLR5 takes aim at bacterial propeller. Nat Immunol 4, 1159–1160 (2003). https://doi.org/10.1038/ni1203-1159