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TLR5 takes aim at bacterial propeller

The Toll-like receptor (TLR) family targets pathogen-derived molecules in regions unlikely to change under selection pressures. For TLR5, which recognizes the protein flagellin, the function of the targeting motif is key.

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Figure 1: Bacteria swim by rotating a flagellum that is attached by a flexible hook to the 'motor', part of which is a disc contained in the membrane.



  1. Janeway, C.A. Jr. Immunol. Today 13, 11–16 (1992).

    CAS  Article  Google Scholar 

  2. Hayashi, F. et al. Nature 410, 1099–1103 (2001).

    CAS  Article  Google Scholar 

  3. Smith, K.D. et al. Nat. Immunol. 4, 1247–1253 (2003).

    CAS  Article  Google Scholar 

  4. Akira, S. Curr. Opin. Immunol. 15, 5–11 (2003).

    CAS  Article  Google Scholar 

  5. Beutler, B. & Rietschel, E.T. Nat. Rev. Immunol. 3, 169–176 (2003).

    CAS  Article  Google Scholar 

  6. Bell, J.K. et al. Trends Immunol. 24, 528–33 (2003).

    CAS  Article  Google Scholar 

  7. Samatey, F.A. et al. Nature 410, 331–337 (2001).

    CAS  Article  Google Scholar 

  8. Zeng, H. et al. J. Immunol. 171, 3668–3674 (2003).

    CAS  Article  Google Scholar 

  9. Gomez-Gomez, L. & Boller, T. Trends Plant Sci. 7, 251–256 (2002).

    CAS  Article  Google Scholar 

  10. Weber, A.N. et al. Nat. Immunol. 4, 794–800 (2003).

    CAS  Article  Google Scholar 

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Reichhart, JM. TLR5 takes aim at bacterial propeller. Nat Immunol 4, 1159–1160 (2003).

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