Proteolytic cleavage generates the peptide repertoire displayed by MHC class I. Now, an interferon-γ–inducible aminopeptidase in the endoplasmic reticulum has been identified as the final player in this complex process.
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Falk, K., Rötzschke, O. The final cut: how ERAP1 trims MHC ligands to size. Nat Immunol 3, 1121–1122 (2002). https://doi.org/10.1038/ni1202-1121
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DOI: https://doi.org/10.1038/ni1202-1121
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