Receptors in the immune system usually specialize in transmitting specific types of signals. However, by associating with two different signaling subunits, the receptor NKG2D can transmit distinct signals for either costimulation or full-fledged activation.
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Long, E. Versatile signaling through NKG2D. Nat Immunol 3, 1119–1120 (2002). https://doi.org/10.1038/ni1202-1119
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