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Somatic evolution of antibody specificity: setting the clock forward

Nature Immunology volume 1, pages 463–464 (2000)Cite this article

A recent paper in Nature sheds welcome light on the mechanism of somatic hypermutation by documenting the participation of double-strand DNA breaks.

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Figure 1: Cell cycle timing and DNA repair in somatic diversification of antibody genes.

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  1. Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA

    Stephen Desiderio

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  1. Stephen Desiderio
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Desiderio, S. Somatic evolution of antibody specificity: setting the clock forward. Nat Immunol 1, 463–464 (2000). https://doi.org/10.1038/82704

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