Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A novel axis of innate immunity in cancer

Nature Immunology volume 11, pages 981–982 (2010)Cite this article

Subjects

Neutrophils can function as chief effector cells in inflammation but can also regulate excessive inflammatory responses by secreting anti-inflammatory cytokines. The acute-phase reactant SAA-1 seems to be pivotal in the control of such plasticity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: NKT cell crosstalk counteracts SAA-1-induced differentiation of immunosuppressive neutrophils.

Marina Corral

References

  1. De Santo, C. et al. Nat. Immunol. 11, 1039–1046 (2010).

    Article  CAS  Google Scholar 

  2. Godfrey, D.I., Stankovic, S. & Baxter, A.G. Nat. Immunol. 11, 197–206 (2010).

    Article  CAS  Google Scholar 

  3. Cerundolo, V., Silk, J.D., Masri, S.H. & Salio, M. Nat. Rev. Immunol. 9, 28–38 (2009).

    Article  CAS  Google Scholar 

  4. Hegde, S., Fox, L., Wang, X. & Gumperz, J.E. Immunology 130, 471–483 (2010).

    Article  CAS  Google Scholar 

  5. Paret, C., Schon, Z., Szponar, A. & Kovacs, G. Eur. Urol. 57, 735–920 (2010).

    Article  Google Scholar 

  6. Tolson, J. et al. Lab. Invest. 84, 845–856 (2004).

    Article  CAS  Google Scholar 

  7. Hatanaka, E., Furlaneto, C.J., Ribeiro, F.P., Souza, G.M. & Campa, A. Immunol. Lett. 91, 33–37 (2004).

    Article  CAS  Google Scholar 

  8. Ribeiro, F.P. et al. Mediators Inflamm. 12, 173–178 (2003).

    Article  CAS  Google Scholar 

  9. Li, L. et al. J. Immunol. 178, 5899–5911 (2007).

    Article  CAS  Google Scholar 

  10. Hwang, S.J., Kim, S., Park, W.S. & Chung, D.H. J. Immunol. 177, 5258–5268 (2006).

    Article  CAS  Google Scholar 

  11. Costantini, C. et al. Int. Immunol. 22, 827–838 (2010).

    Article  CAS  Google Scholar 

  12. Costantini, C. & Cassatella, M.A. J. Leukoc. Biol. published online, doi:jlb.0510250 (3 August 2010).

  13. Dhodapkar, M.V. et al. J. Exp. Med. 197, 1667–1676 (2003).

    Article  CAS  Google Scholar 

  14. Kunii, N. et al. Cancer Sci. 100, 1092–1098 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Stephen R. Mattarollo and Mark J. Smyth are with the Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.,

    Stephen R Mattarollo & Mark J Smyth

Authors
  1. Stephen R Mattarollo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark J Smyth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark J Smyth.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mattarollo, S., Smyth, M. A novel axis of innate immunity in cancer. Nat Immunol 11, 981–982 (2010). https://doi.org/10.1038/ni1110-981

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1110-981

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer