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IFN-γ and self-absorbed CD4+ T cells: a regulatory double negative

Nature Immunology volume 9, pages 1210–1212 (2008)Cite this article

Interferon-γ exerts many effects on the immune system. A new report shows that it induces both autophagy and Irgm1, a GTPase that protects activated CD4+ T cells from executing autophagy.

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Figure 1: IFN-γ drives a regulatory double negative.

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Authors and Affiliations

  1. Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, 45229, Ohio, USA

    David Hildeman

  2. Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, 45229, Ohio, USA

    Edith Janssen

Authors
  1. David Hildeman
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  2. Edith Janssen
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Hildeman, D., Janssen, E. IFN-γ and self-absorbed CD4+ T cells: a regulatory double negative. Nat Immunol 9, 1210–1212 (2008). https://doi.org/10.1038/ni1108-1210

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