News & Views | Published:

IFN-γ and self-absorbed CD4+ T cells: a regulatory double negative

Nature Immunology volume 9, pages 12101212 (2008) | Download Citation

Interferon-γ exerts many effects on the immune system. A new report shows that it induces both autophagy and Irgm1, a GTPase that protects activated CD4+ T cells from executing autophagy.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Dev. Cell 6, 463–477 (2004).

  2. 2.

    et al. Cell 119, 753–766 (2004).

  3. 3.

    et al. Science 306, 1037–1040 (2004).

  4. 4.

    , , , & J. Exp. Med. 204, 25–31 (2007).

  5. 5.

    et al. Nat. Immunol. 9, 1279–1287 (2008).

  6. 6.

    et al. J. Immunol. 172, 1163–1168 (2004).

  7. 7.

    , , & J. Exp. Med. 196, 999–1005 (2002).

  8. 8.

    & Nat. Cell Biol. 9, 1102–1109 (2007).

  9. 9.

    , , & Science 313, 1438–1441 (2006).

  10. 10.

    & Magn. Reson. Med. 29, 317–326 (1993).

  11. 11.

    , & Nat. Rev. Immunol. 5, 844–852 (2005).

  12. 12.

    et al. Immunity 28, 197–205 (2008).

  13. 13.

    et al. Immunity 28, 206–217 (2008).

  14. 14.

    et al. Immunity 28, 218–230 (2008).

  15. 15.

    et al. Eur. J. Immunol. 36, 1694–1706 (2006).

Download references

Author information

Affiliations

  1. Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.  hilsv5@cchmc.org

    • David Hildeman
  2. Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.

    • Edith Janssen

Authors

  1. Search for David Hildeman in:

  2. Search for Edith Janssen in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ni1108-1210

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing