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The early days of the HIV-AIDS epidemic in the USA

The work of epidemiologists before the isolation of human immunodeficiency virus 25 years ago demonstrates the power of the epidemiological method to gain an understanding of disease pathogenesis.

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Figure 1: Cluster of AIDS cases for patients linked by sexual contact.


  1. Barre-Sinoussi, F. et al. Science 220, 868–871 (1983).

    Article  CAS  Google Scholar 

  2. CDC. MMWR Morb. Mortal. Wkly. Rep. 30, 250–252 (1981). [cite in text]

  3. Centers for Disease Control Task Force on Kaposi's Sarcoma and Opportunistic Infections. N. Engl. J. Med. 306, 248–252 (1982).

  4. CDC. MMWR Morb. Mortal. Wkly. Rep. 30, 305–308 (1981).

  5. Sonnabend, J.A., Witkin, S.S. & Purtilo, D.T. Ann. NY Acad. Sci. 437, 177–183 (1984).

    Article  CAS  Google Scholar 

  6. Jaffe, H.W. et al. Ann. Intern. Med. 99, 145–151 (1983).

    Article  CAS  Google Scholar 

  7. Auerbach, D.M., Darrow, W.W., Jaffe, H.W. & Curran, J.W. Am. J. Med. 76, 487–492 (1984).

    Article  CAS  Google Scholar 

  8. CDC. MMWR Morb. Mortal. Wkly. Rep. 31, 652–654 (1982).

  9. CDC. MMWR Morb. Mortal. Wkly. Rep. 31, 665–667 (1982).

  10. CDC. MMWR Morb. Mortal. Wkly. Rep. 31, 697–698 (1983).

  11. CDC. MMWR Morb. Mortal. Wkly. Rep. 32, 101–104 (1983).

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Jaffe, H. The early days of the HIV-AIDS epidemic in the USA. Nat Immunol 9, 1201–1203 (2008).

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