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Linking diacylglycerol kinase to T cell anergy

Nature Immunology volume 7, pages 1132–1134 (2006)Cite this article

Understanding of the signaling networks regulating T cell anergy remains incomplete. Two reports now demonstrate that alterations in diacylglycerol metabolism regulate the adoption of an anergic versus an activated T cell fate.

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Figure 1: Altered diacylglycerol metabolism uncouples the hydrolysis of phosphatidylinositol-4,5-bisphosphate from the activation of Ras in clonal anergy.

Kim Caesar

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  1. Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, 55455, Minnesota, USA

    Daniel L Mueller

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  1. Daniel L Mueller
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Mueller, D. Linking diacylglycerol kinase to T cell anergy. Nat Immunol 7, 1132–1134 (2006). https://doi.org/10.1038/ni1106-1132

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