Contacts between T cell receptors and peptide–major histocompatibility complex molecules require specific amino acid interactions. However, some amino acids have no direct involvement in contact but nevertheless are critical for specificity.
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Felix, N., Allen, P. Learning from the lost: new insights into TCR specificity. Nat Immunol 7, 1127–1128 (2006). https://doi.org/10.1038/ni1106-1127
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DOI: https://doi.org/10.1038/ni1106-1127
