CD28-B7 bidirectional signaling: a two-way street to activation

Engagement of CD28 by B7 molecules results in the activation of T cells. In addition to this T cell stimulation through CD28, the engagement of B7 on dendritic cells by CD28 can lead to the activation of dendritic cells.

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Figure 1: Distinct effector responses in DCs treated with CTLA-4–Ig and CD28-Ig.

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Logue, E., Sha, W. CD28-B7 bidirectional signaling: a two-way street to activation. Nat Immunol 5, 1103–1105 (2004). https://doi.org/10.1038/ni1104-1103

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