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I-Tim-izing the pathways of counter-regulation

Nature Immunology volume 4, pages 1050–1052 (2003)Cite this article

Tim-3, a member of the T cell immunoglobulin mucin family, is expressed by TH1 cells. Analysis of Tim-3–Tim3 ligand signaling now shows this pathway is intimately involved in the counter-regulation of T helper type 1 immune responses.

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Figure 1: Potential mechanisms of immunoregulation by Tim-3 and Tim-3 ligands.

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Authors and Affiliations

  1. Divisions of Immunobiology and Molecular Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, 45208, Ohio, USA

    Marsha Wills-Karp, Yasmine Belkaid & Christopher L Karp

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  1. Marsha Wills-Karp
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  2. Yasmine Belkaid
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  3. Christopher L Karp
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Wills-Karp, M., Belkaid, Y. & Karp, C. I-Tim-izing the pathways of counter-regulation. Nat Immunol 4, 1050–1052 (2003). https://doi.org/10.1038/ni1103-1050

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