Patients with type 2 Hermansky-Pudlak syndrome are immunodeficient. Mutations in AP-3 that prevent movement of lytic granules along microtubules in CD8+ T cells help explain these patients' susceptibility to infection.
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Del Val, M., Yewdell, J. The latest killer AP. Nat Immunol 4, 1049–1050 (2003). https://doi.org/10.1038/ni1103-1049
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DOI: https://doi.org/10.1038/ni1103-1049
