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Slick signaling

Lipid second messengers are thought to be important in T cell activation. Two studies show the spatial-temporal organization of these lipids during immunological synapse formation and raise new questions about their functions.

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Figure 1: Schematic diagram of PIP3 production and recruitment of signaling proteins to the membrane.

K. R.

References

  1. Cantley, L.C. Science 296, 1655–1657 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Harriague & Bismuth, G. Nature Immunol. 3, 1090–1096 (2002).

    Article  CAS  Google Scholar 

  3. Costello, P.S., Gallagher, M. & Cantrell, D.A. Nature Immunol. 3, 1082–1089 (2002).

    Article  CAS  Google Scholar 

  4. Rameh, L.E. & Cantley, L.C. J. Biol. Chem. 274, 8347–8350 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Fruman, D.A., Rameh, L.E. & Cantley, L.C. Cell 97, 817–820 (1999).

    Article  CAS  PubMed  Google Scholar 

  6. Hurley, J.H. & Meyer, T. Curr. Opin. Cell Biol. 13, 146–152 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Teruel, M.N. & Meyer, T. Cell 103, 181–184 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Shaw, A.S. Immunity 15, 683–686 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Lee, K.H. et al. Science 295, 1539–1542 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Ward, S.G. & Cantrell, D.A. Curr. Opin. Immunol. 13, 332–338 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Iezzi, G., Karjalainen, K. & Lanzavecchia, A. Immunity 8, 89–95 (1998).

    Article  CAS  PubMed  Google Scholar 

  12. van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Nature Immunol 2, 423–429 (2001).

    Article  CAS  Google Scholar 

Download references

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Shaw, AY. Slick signaling. Nat Immunol 3, 1058–1059 (2002). https://doi.org/10.1038/ni1102-1058

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