Positive selection in a Schnurri

Regulation of the transcription factor Shn-2 by signals emanating from the TCR can distinguish positive from negative selection of developing thymocytes.

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Figure 1: Highly simplified Dpp and TGF-β superfamily signaling pathways.

Bob Crimi

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Gascoigne, N. Positive selection in a Schnurri. Nat Immunol 2, 989–991 (2001). https://doi.org/10.1038/ni1101-989

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