The “two-signal” model proposes that immature DCs that deliver signal 1 in the absence of signal 2 cross-tolerize CD8+ T cells. New evidence shows that mature DCs are required for both cross-tolerance and cross-priming.
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References
Mellman, I. & Steinman, R. M. Cell 106, 255–258 (2001).
Albert, M. L., Jegathesan, M. & Darnell, R. B. Nature Immunol. 2, 1010–1017 (2001).
Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. & Heath, W. R. J. Exp. Med. 186, 239–245 (1997).
Heath, W. R. & Carbone, F. R. Annu. Rev. Immunol. 19, 47–64 (2001).
Bennett, S. R. et al. Nature 393, 478–480 (1998).
de St Groth, B. Immunol. Today 19, 448–254 (1998).
Süss, G. & Shortman, K. J. Exp. Med. 183, 1789–1796 (1996).
Kamath, A. et al. J. Immunol. 165, 6762–6770 (2000).
Bennett, S. R., Carbone, F. R., Karamalis, F., Miller, J. F. & Heath, W. R. J. Exp. Med. 186, 65–70 (1997).
Ridge, J. P., Di Rosa, F. & Matzinger, P. Nature 393, 474–478 (1998).
Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. & Melief, C. J. Nature 393, 480–483 (1998).
Guerder, S. & Matzinger, P. J. Exp. Med. 176, 553–564 (1992).
Adler, A. J. et al. J. Exp. Med. 187, 1555–1564 (1998).
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Shortman, K., Heath, W. Immunity or tolerance? That is the question for dendritic cells. Nat Immunol 2, 988–989 (2001). https://doi.org/10.1038/ni1101-988
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DOI: https://doi.org/10.1038/ni1101-988
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