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IAPP boosts islet macrophage IL-1 in type 2 diabetes

Nature Immunology volume 11, pages 881–883 (2010)Cite this article

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A Corrigendum to this article was published on 15 February 2011

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IAPP, a hormone secreted together with insulin and deposited in pancreatic islets in type 2 diabetes, can induce macrophage processing of interleukin 1 linked to beta-cell destruction in type 2 diabetes.

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Figure 1: The beta cell in type 2 diabetes: under fire from friend and foe.

Change history

  • 21 October 2010

    In the version of this article initially published, some of the text on p 882 was inaccurate. The correct text should read as follows: “thereby counteracting the beneficial effects of blocking IAPP on islet inflammation” (middle column) and “This mechanism has been suggested to mediate ROS-dependent inflammasome activation induced by high concentrations of glucose in mouse pancreatic beta cells12, although this finding is now being debated” (right column, first full paragraph, second sentence). The errors have been corrected in the HTML and PDF versions of the article.

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  1. Thomas Mandrup-Poulsen is in the Department for Biomedical Sciences, Denmark and the Department of Medicine and Surgery, University of Copenhagen, Copenhagen, the Hagedorn Research Institute, Gentofte, Karolinska Institutet, Stockholm, Sweden.,

    Thomas Mandrup-Poulsen

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  1. Thomas Mandrup-Poulsen
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Correspondence to Thomas Mandrup-Poulsen.

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T.M.-P. is a part-time employee of and owns shares in Novo Nordisk.

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Mandrup-Poulsen, T. IAPP boosts islet macrophage IL-1 in type 2 diabetes. Nat Immunol 11, 881–883 (2010). https://doi.org/10.1038/ni1010-881

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