Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Beyond peptidoglycan for Nod2

Nod2 is a cytoplasmic Nod-like receptor protein that detects the peptidoglycan subfragment muramyl dipeptide. New work shows that Nod2 also has an important role in recognizing viruses and in triggering interferon production during viral infection.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pathways of Nod2 activation.

References

  1. Inohara, C., McDonald, C. & Nunez, G. Annu. Rev. Biochem. 74, 355–383 (2005).

    Article  CAS  Google Scholar 

  2. Sabbah, A. et al. Nat. Immunol. 10, 1073–1080 (2009).

    Article  CAS  Google Scholar 

  3. Kobayashi, K.S. et al. Science 307, 731–734 (2005).

    Article  CAS  Google Scholar 

  4. Pauleau, A.L. & Murray, P.J. Mol. Cell. Biol. 23, 7531–7539 (2003).

    Article  CAS  Google Scholar 

  5. Franchi, L., Eigenbrod, T., Munoz-Planillo, R. & Nunez, G. Nat. Immunol. 10, 241–247 (2009).

    Article  CAS  Google Scholar 

  6. Bertrand, M.J. et al. Immunity 30, 789–801 (2009).

    Article  CAS  Google Scholar 

  7. Krieg, A. et al. Proc. Natl. Acad. Sci. USA (in the press) (2009).

    Google Scholar 

  8. Seth, R.B., Sun, L., Ea, C.K. & Chen, Z.J. Cell 122, 669–682 (2005).

    Article  CAS  Google Scholar 

  9. Moore, C.B. et al. Nature 451, 573–577 (2008).

    Article  CAS  Google Scholar 

  10. Owen, D.M. & Gale, M. Jr . Immunity 30, 476–478 (2009).

    Article  CAS  Google Scholar 

  11. Strober, W., Murray, P.J., Kitani, A. & Watanabe, T. Nat. Rev. Immunol. 6, 9–20 (2006).

    Article  CAS  Google Scholar 

  12. Chang, E.Y., Guo, B., Doyle, S.E. & Cheng, G. J. Immunol. 178, 6705–6709 (2007).

    Article  CAS  Google Scholar 

  13. Moreira, L.O. et al. Cell. Microbiol. 10, 2067–2077 (2008).

    Article  CAS  Google Scholar 

  14. Noguchi, E. et al. Nat. Immunol. 10, 471–479 (2009).

    Article  CAS  Google Scholar 

  15. Pandey, A.K. et al. PLoS Pathog. 5, e1000500 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Murray, P. Beyond peptidoglycan for Nod2. Nat Immunol 10, 1053–1054 (2009). https://doi.org/10.1038/ni1009-1053

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1009-1053

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing