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A-Miz-ing BCL6

Germinal center formation requires BCL6 to silence specific genes in B cells. New data now show that the repertoire of genes repressed by BCL6 is larger than previously thought, because of its interaction with the DNA-binding protein Miz-1.

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Figure 1: BCL6 actively suppresses Miz-1-dependent transcription of CDKN1A.

Katie Ris

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Wu, X., Jelinek, D. A-Miz-ing BCL6. Nat Immunol 6, 964–966 (2005). https://doi.org/10.1038/ni1005-964

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