The adaptor SAP mediates activation signals in natural killer cells. However, its family members EAT-2 and ERT are negative regulators that help to fine-tune natural killer cell recognition of viruses and tumors.
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Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells
Scientific Reports Open Access 05 December 2014
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Colonna, M. Fine-tuning NK cell responses: it's a family affair. Nat Immunol 6, 961–962 (2005). https://doi.org/10.1038/ni1005-961
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DOI: https://doi.org/10.1038/ni1005-961
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