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Can we apply the TH1-TH2 paradigm to all lymphocytes?

Nature Immunology volume 2, pages 899–900 (2001)Cite this article

The TH1-TH2 paradigm, in which CD4+ T cells polarize into type 1 or type 2 helper cells, has been extended to other cells types. However, evidence now suggests that NK cells differentiate sequentially from immature type 2 to mature type 1 cells, a pathway that could apply to other lymphocytes.

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Figure 1: According to the TH1-TH2 paradigm (a), NK cell precursors (pre-NK) differentiate into NK cells producing either type 1 (NK1) or type 2 (NK2) cytokines, paralleling differentiation of TH precursors (pre-TH) into TH1 and TH2.

Bob Crimi

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  1. Basel Institute for Immunology, 487 Grenzacherstrasse, Basel, CH-4005, Switzerland

    Marco Colonna

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  1. Marco Colonna
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Colonna, M. Can we apply the TH1-TH2 paradigm to all lymphocytes?. Nat Immunol 2, 899–900 (2001). https://doi.org/10.1038/ni1001-899

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