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Innate sensing of nickel

Nature Immunology volume 11, pages 781–782 (2010)Cite this article

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Although nickel allergy is very common, the specific receptor for nickel has not been identified. TLR4 is now shown to bind nickel and cause inflammation, an interaction that is specific to humans.

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Figure 1: Contact allergy, shown as erythema in this figure, is commonly induced by nickel ions present in nickel-containing jewelry such as rings and earrings, as well as in nickel-containing cellular telephones.

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Authors and Affiliations

  1. Marc E. Rothenberg is in the Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.,

    Marc E Rothenberg

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  1. Marc E Rothenberg
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Correspondence to Marc E Rothenberg.

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The author declares no competing financial interests.

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Rothenberg, M. Innate sensing of nickel. Nat Immunol 11, 781–782 (2010). https://doi.org/10.1038/ni0910-781

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  • DOI: https://doi.org/10.1038/ni0910-781

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