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From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development

Nature Immunology volume 10, pages 929–932 (2009)Cite this article

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to TH1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of TH1 cells.

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Acknowledgements

We thank other research assistants, PhD students, postdoctoral fellows and collaborators who have worked with us through the years and contributed to our work and apologize that we have not been able to include all here. We also thank our colleagues at DNAX and in the Department of Pathology at Washington University for their support and interaction. We thank P. Vieira for comments and reading of the manuscript.

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Authors and Affiliations

  1. Anne O'Garra is with the Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK. aogarra@nimr.mrc.ac.uk,

    Anne O'Garra

  2. Kenneth M. Murphy is in the Department of Pathology and Centre for Immunology, Howard Hughes Medical Institute, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA. kmurphy@wustl.edu,

    Kenneth M Murphy

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O'Garra, A., Murphy, K. From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development. Nat Immunol 10, 929–932 (2009). https://doi.org/10.1038/ni0909-929

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