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NK cell tolerance: revisiting the central dogma

Physiological tolerance of natural killer (NK) cells to self tissues is believed to require the expression of at least one inhibitory receptor specific for self MHC. This dogma may require revision with the identification of self-tolerant NK cells lacking self MHC–specific receptors.

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Figure 1: Two types of self-tolerant NK cells in normal mice.


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MacDonald, H. NK cell tolerance: revisiting the central dogma. Nat Immunol 6, 868–869 (2005).

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