Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A passport into the lymph node

Nature Immunology volume 6, pages 866–868 (2005)Cite this article

Lymphocytes continuously recirculate throughout the body. Evidence now suggests chemokine receptor CCR7 actively controls lymphocyte entry into afferent lymphatic vessels.

T cells constantly move in and out of lymph nodes. The mechanisms that direct T cells to enter lymph nodes from blood and to exit lymph nodes back into the circulation (via efferent lymphatics) are reasonably well understood1. However, the mechanisms underlying their re-entry from the periphery into afferent lymphatics and lymph nodes have remained a mystery so far. New results presented by two reports in this issue of Nature Immunology establish the chemokine receptor CCR7 as a key molecule in the return of T cells to lymph nodes from peripheral tissues2,3.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Figure 1: CCR7 is a 'passport' for T cell entry into lymph nodes.

Katie Ris

References

  1. Cyster, J.G. Annu. Rev. Immunol. 23, 127–159 (2005).

    CAS  Article  Google Scholar 

  2. Debes, G.F. et al. Nat. Immunol. 6, 889–894 (2005).

    CAS  Article  Google Scholar 

  3. Bromley, S.K., Thomas, S.Y. & Luster, A.D. Nat. Immunol. 6, 895–901 (2005).

    CAS  Article  Google Scholar 

  4. Gunn, M.D. et al. Proc. Natl. Acad. Sci. USA 95, 258–263 (1998).

    CAS  Article  Google Scholar 

  5. Forster, R. et al. Cell 99, 23–33 (1999).

    CAS  Article  Google Scholar 

  6. Gunn, M.D. et al. J. Exp. Med. 189, 451–460 (1999).

    CAS  Article  Google Scholar 

  7. Sallusto, F., Geginat, J. & Lanzavecchia, A. Annu. Rev. Immunol. 22, 745–763 (2004).

    CAS  Article  Google Scholar 

  8. Randolph, G.J., Sanchez-Schmitz, G. & Angeli, V. Springer Semin. Immunopathol. 26, 273–287 (2005).

    Article  Google Scholar 

  9. Hjelmstrom, P. et al. Am. J. Pathol. 156, 1133–1138 (2000).

    CAS  Article  Google Scholar 

  10. Martin, A.P. et al. J. Immunol. 173, 4791–4798 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. Immunobiology Center, Mt. Sinai School of Medicine, New York, 10029, New York, USA

    Sergio A Lira

Authors
  1. Sergio A Lira
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lira, S. A passport into the lymph node. Nat Immunol 6, 866–868 (2005). https://doi.org/10.1038/ni0905-866

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0905-866

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing