Although CD4+ T cell help is required for effective pathogen control, persistent antiviral CD4+ T cell help can, paradoxically, impair the generation of neutralizing antibody responses and thus potentially limit protective immunity.
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Homann, D., Gill, R. To help and help not. Nat Immunol 5, 878–880 (2004). https://doi.org/10.1038/ni0904-878
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DOI: https://doi.org/10.1038/ni0904-878
