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A peek at PIAS

Nature Immunology volume 5, pages 875–876 (2004)Cite this article

Members of the PIAS family can negatively regulate the cytokine-activated Jak-STAT pathway in vitro. One member of this family, PIAS1, is a nonredundant and physiologic regulator of certain STAT1-dependent interferon-induced genes.

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Figure 1: PIAS1 regulates interferon-dependent signaling by binding STAT1 and inhibiting a subset of interferon-inducible genes.

K.R.

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Authors and Affiliations

  1. Molecular Immunology and Inflammation Branch of the National Institute of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, 20852, Maryland, USA

    John J O'Shea & Wendy Watford

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  1. John J O'Shea
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  2. Wendy Watford
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O'Shea, J., Watford, W. A peek at PIAS. Nat Immunol 5, 875–876 (2004). https://doi.org/10.1038/ni0904-875

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